Reply To: STABILITY OF STREPTOKINASE INJ

I’ve always also been through using Alteplase for the purpose of catheter occlusion in HD patients. However, it was an excellent opportunity to revise the use of streptokinase for such purpose.

Kindly find the below:-

1- Stability was found to be (8) hours in room temperature due to risk of contamination.

2- Stability was found to be (24) hours in refrigerator

 

(Attached are detailed and highlighted references from Trissel IV Manual)

 

3- I’d like to go with Naveed regarding the preferable use of Alteplase over Streptokinase because:-

 

1. A) Stability of reconstituted Alteplase at concentration of (1mg/ml) in SWFI then frozen at (-20 C) is (6 months in polypropylene syringes) and (32 days in glass vials).

(Reference:- HandBook on injectable drugs 18^th Edition)

1. B) Lower risk of complications than streptokinase

Thanks for such refreshing inquiry.