First Order Vs. Zero Order Kinetics

Trying to understand first order and zero order kinetics

{My own study points.}

                <h3><strong>First Order Kinetics</strong></h3><ul><li><span><strong>Higher </strong>plasma concentrations means <strong>higher </strong>metabolization rate.</span></li><li><span>Metabolism is <strong>directly </strong>proportional with drug concentrations.</span></li><li><span>Drug is eliminated from the body related to the plasma levels.</span></li><li><span><strong>Constant </strong>half-life. (Metabolize 50% of drug)</span></li></ul>                    <h3><strong>Zero Order Kinetics</strong></h3><ul><li>                    <span><strong>Higher&nbsp;</strong>plasma concentrations <strong>doesn't </strong>mean <strong>higher&nbsp;</strong>metabolization rate.</span></li><li>                    <span>Metabolism is&nbsp;<b>independent&nbsp;</b>from plasma concentrations.</span></li><li>                    <span>Drug concentration in the body increase with time disregarding the elimination rate leading to toxic side effects.</span></li><li>                    <span><strong>Constant </strong>rate of drug metabolism.</span></li></ul><h3>Conclusion:</h3>First order is <strong>Good</strong>, Zero order is <strong>BAD</strong>.

First order is occurring with most medications.

First order: constant proportion of the drug is eliminated per unit time.Zero order: constant amount of the drug is eliminated per unit time.