Liposomal amphotericin B is a “lonely” drug, it is strictly to be run alone in a dedicated line as per all references. As said before, it is preferable whenever possible (i know it gets really hard in intensive care settings!!) but drugs should not be added to PN – there’s a small number that is added like heparin at the time of compounding etc but in general no.
As for the caloric content of liposomal amphotericin B, the lipid portion contains 0.27kcal per 5mg. Hence you could argue that for patients receiving PN, adjustment to lipid content might be deemed necessary (Ref: Sacks 1997).
